Two hundred years after Mary Shelley's novel the brilliant but mad Doctor (Thomas Kretschmann) has sustained his creature and himself over two centuries through genetic experimentation. In present-day America Detective O'Connor (Parker Posey) is investigating a series of horrific murders which leads her to the doctor and his creature. What she uncovers reveals the strange evolution the doctor and his creation undergo over the course of two centuries and the divergent paths creator and monster take in pursuing good or evil. 在玛丽·雪莱的小说两百年后，才华横溢但张狂的医师使他自己和他的怪物从两个世纪前的最初的试验一向幸存下来。现在，美国捕快 O'Connor 在查询系列谋杀案时，被引向了医师和他的怪物，并揭穿出在长达两个多世纪的漫长岁月中，医师和他著作间的独特演化和他们踏上善与恶的不同路途。
